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Effect of increasing the dose and duration of sertraline trial in the treatment of depressed nursing home residents.
- Source :
-
Journal of geriatric psychiatry and neurology [J Geriatr Psychiatry Neurol] 2003 Jun; Vol. 16 (2), pp. 109-11. - Publication Year :
- 2003
-
Abstract
- There has been limited research into defining what constitutes an adequate first-line antidepressant trial in elderly patients. The authors report the outcome of extended, high-dosage sertraline treatment in a sample of nursing home residents experiencing residual significant depressive symptoms after 10 weeks of treatment with sertraline at a final dosage of 100 mg/day. Subjects who had a Hamilton Depression Rating Scale score > or = 12 after 10 weeks of treatment with sertraline were eligible for the 8-week open-label extension phase, which involved titrating the sertraline dosage to 200 mg/day. The cumulative response rate was 52% for the extension phase, compared with 37% for the acute phase. Examining acute phase nonresponders, 39% responded during the extension phase. Rates of discontinuation due to adverse events were comparable in the 2 phases. Our findings suggest that an extended trial or high dosages of sertraline may benefit some depressed elderly patients with persistent depression after acute treatment.
- Subjects :
- Acute Disease
Aged
Aged, 80 and over
Depressive Disorder, Major diagnosis
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Male
Severity of Illness Index
Surveys and Questionnaires
Depressive Disorder, Major drug therapy
Nursing Homes
Selective Serotonin Reuptake Inhibitors therapeutic use
Sertraline therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0891-9887
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of geriatric psychiatry and neurology
- Publication Type :
- Academic Journal
- Accession number :
- 12801161
- Full Text :
- https://doi.org/10.1177/0891988703016002008