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The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial.
- Source :
-
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2003 Jun; Vol. 25 (6), pp. 513-8. - Publication Year :
- 2003
-
Abstract
- Objective: ischaemic lower-extremity ulcers in the diabetic population are a source of major concern because of the associated high risk of limb-threatening complications. The aim of this study was to evaluate the role of hyperbaric oxygen in the management of these ulcers.<br />Method: eighteen diabetic patients with ischaemic, non-healing lower-extremity ulcers were recruited in a double-blind study. Patients were randomly assigned either to receive 100% oxygen (treatment group) or air (control group), at 2.4 atmospheres of absolute pressure for 90 min daily (total of 30 treatments).<br />Results: healing with complete epithelialisation was achieved in five out of eight ulcers in the treatment group compared to one out of eight ulcers in the control group. The median decrease of the wound areas in the treatment group was 100% and in the control group was 52% (p=0.027). Cost-effectiveness analysis has shown that despite the extra cost involved in using hyperbaric oxygen, there was a potential saving in the total cost of treatment for each patient during the study.<br />Conclusion: hyperbaric oxygen enhanced the healing of ischaemic, non-healing diabetic leg ulcers and may be used as a valuable adjunct to conventional therapy when reconstructive surgery is not possible.
- Subjects :
- Aged
Aged, 80 and over
Anxiety economics
Anxiety psychology
Cost-Benefit Analysis economics
Depression economics
Depression psychology
Depression therapy
Diabetic Foot economics
Diabetic Foot psychology
Double-Blind Method
Female
Follow-Up Studies
Humans
Ischemia economics
Ischemia psychology
Leg Ulcer economics
Leg Ulcer psychology
Lower Extremity pathology
Male
Middle Aged
Quality of Life
Treatment Outcome
United Kingdom
Diabetic Foot therapy
Hyperbaric Oxygenation economics
Ischemia therapy
Leg Ulcer therapy
Lower Extremity blood supply
Subjects
Details
- Language :
- English
- ISSN :
- 1078-5884
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 12787692
- Full Text :
- https://doi.org/10.1053/ejvs.2002.1911