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Agmatine reduces hydrogen peroxide in mesangial cells under high glucose conditions.
- Source :
-
Journal of biochemistry and molecular biology [J Biochem Mol Biol] 2003 May 31; Vol. 36 (3), pp. 251-7. - Publication Year :
- 2003
-
Abstract
- Agmatine, an amine and organic cation, reduced H(2)O(2) that was generated by hyperglycemia, and transcription factors such as NF-kappaB and AP-1 activity in the mesangial cells that were exposed to high glucose. However, spermine which shares a strong nucleophilic structure with agmatine decreased the H(2)O(2) levels and AP-1, but not the NF-kappaB activity. Possible roles for agmatine and spermine in decreasing fibronectin are discussed, and the signaling pathway for agmatine-reduced fibronectin accumulation is presented.
- Subjects :
- Agmatine metabolism
Animals
Cells, Cultured
Dose-Response Relationship, Drug
Fibronectins metabolism
Glomerular Mesangium cytology
Glomerular Mesangium metabolism
Mice
NF-kappa B metabolism
Polyamines pharmacology
Reactive Oxygen Species metabolism
Signal Transduction
Spermine pharmacology
Transcription Factor AP-1 metabolism
Agmatine pharmacology
Glomerular Mesangium drug effects
Glucose pharmacology
Hydrogen Peroxide metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1225-8687
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of biochemistry and molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 12787478
- Full Text :
- https://doi.org/10.5483/bmbrep.2003.36.3.251