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Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Jun 16; Vol. 13 (12), pp. 1981-4. - Publication Year :
- 2003
-
Abstract
- Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.
- Subjects :
- Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Humans
Inhibitory Concentration 50
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Quinolines chemical synthesis
Recombinant Proteins antagonists & inhibitors
Reference Values
Structure-Activity Relationship
Amines chemistry
Nitric Oxide Synthase antagonists & inhibitors
Quinolines chemistry
Quinolines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 13
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 12781178
- Full Text :
- https://doi.org/10.1016/s0960-894x(03)00351-2