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An immunohistochemical study of the 'snowbank' in a case of pars planiti.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2002 Jun; Vol. 10 (2), pp. 117-23. - Publication Year :
- 2002
-
Abstract
- Purpose: To characterize the extracellular matrix and cellular components of a 'snowbank' removed during vitreous surgery for treatment of retinal detachment complicating pars planitis.<br />Methods: The 'snowbank' was examined using immunohistochemical techniques and a panel of monoclonal and polyclonal antibodies directed against glial fibrillary acidic protein (GFAP), cytokeratin, alpha smooth muscle actin, tenascin, laminin, fibronectin, and collagen types I, II, and III.<br />Results: The 'snowbank' was acellular except on the uveal side where there were cytokeratin-positive retinal pigment epithelial cells. There were no cells positive for the glial cell marker GFAP and the myofibroblast cell marker alpha smooth muscle actin. The extracellular matrix of the 'snowbank' contained tenascin and collagen types I, II, and III. There was no immunoreactivity for laminin and fibronectin.<br />Conclusion: These results on the immunohistochemical components of the 'snowbank' may be useful in clarifying the nature of the chronic inflammatory process in pars planitis. They indicate extensive tissue repair and remodeling, leading to major loss of function.
- Subjects :
- Actins metabolism
Antibodies, Monoclonal
Child
Collagen metabolism
Extracellular Matrix pathology
Female
Fibronectins metabolism
Glial Fibrillary Acidic Protein metabolism
Humans
Immunoenzyme Techniques
Keratins metabolism
Laminin metabolism
Lens, Crystalline surgery
Pars Planitis complications
Pars Planitis pathology
Retinal Detachment etiology
Retinal Detachment pathology
Retinal Detachment surgery
Scleral Buckling
Tenascin metabolism
Vitrectomy
Extracellular Matrix metabolism
Extracellular Matrix Proteins metabolism
Pars Planitis metabolism
Retinal Detachment metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0927-3948
- Volume :
- 10
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 12778347
- Full Text :
- https://doi.org/10.1076/ocii.10.2.117.13980