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Dexamethasone treatment does not inhibit fibroproliferation in chronic lung disease of prematurity.
- Source :
-
The European respiratory journal [Eur Respir J] 2003 May; Vol. 21 (5), pp. 842-7. - Publication Year :
- 2003
-
Abstract
- Pulmonary fibrosis results from excessive fibroblast proliferation and increased collagen deposition and occurs in chronic lung disease of prematurity (CLD). Platelet-derived growth factor (PDGF)-BB is mitogenic for fibroblasts and levels are increased in fibrotic lung disorders. Systemic dexamethasone (DEX) treatment improves pulmonary function and reduces inflammation in infants with or at risk of CLD. However, the effect of DEX treatment on fibroblast activity, PDGF-BB and collagen synthesis in the lungs of CLD patients is uncertain. Bronchoalveolar lavage (BAL) fluids, obtained from 15 infants at risk of CLD before and after DEX treatment, were analysed for fibroblast mitogenicity, PDGF-BB, N-terminal propeptide of collagen type III (PIIINP) and interleukin (IL)-1beta levels and inflammatory cell numbers. After DEX treatment, the mitogenic activity of BAL fluid for fibroblasts was not reduced but increased. The change in mitogenicity correlated with a change in BAL fluid PDGF-BB levels. Furthermore, BAL fluid-induced fibroblast proliferation was blocked using an inhibitor of the PDGF receptor. DEX treatment did not influence PIIINP levels, but reduced IL-1beta levels and inflammatory cell numbers in BAL fluid. This study suggests that dexamethasone treatment does not reduce fibroblast proliferation despite apparent downregulation of inflammation. The present findings do not support the use of dexamethasone for prevention of the fibrotic response in infants at risk of chronic lung disease of prematurity.
- Subjects :
- Bronchoalveolar Lavage Fluid cytology
Fibroblasts physiology
Humans
Infant, Newborn
Infant, Premature
Pulmonary Fibrosis etiology
Respiratory Distress Syndrome, Newborn complications
Anti-Inflammatory Agents therapeutic use
Bronchoalveolar Lavage Fluid immunology
Dexamethasone therapeutic use
Pulmonary Fibrosis prevention & control
Respiratory Distress Syndrome, Newborn drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0903-1936
- Volume :
- 21
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The European respiratory journal
- Publication Type :
- Academic Journal
- Accession number :
- 12765431
- Full Text :
- https://doi.org/10.1183/09031936.03.00069002