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Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2003 Jun; Vol. 47 (6), pp. 2047-50. - Publication Year :
- 2003
-
Abstract
- We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
- Subjects :
- Alkyl and Aryl Transferases metabolism
Animals
Dose-Response Relationship, Drug
Ergosterol metabolism
Farnesyl-Diphosphate Farnesyltransferase metabolism
Geranyltranstransferase
Humans
Microbial Sensitivity Tests
Trypanosoma cruzi enzymology
Trypanosoma cruzi growth & development
Trypanosoma cruzi metabolism
Phenyl Ethers pharmacology
Thiocyanates pharmacology
Trypanocidal Agents pharmacology
Trypanosoma cruzi drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 47
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 12760897
- Full Text :
- https://doi.org/10.1128/AAC.47.6.2047-2050.2003