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Long-term effectiveness of risperidone and olanzapine in resistant or intolerant schizophrenic patients. A mirror study.
- Source :
-
Acta psychiatrica Scandinavica [Acta Psychiatr Scand] 2003 May; Vol. 107 (5), pp. 344-50. - Publication Year :
- 2003
-
Abstract
- Objective: To evaluate the long-term effectiveness of the second generation antipsychotics, risperidone and olanzapine on hospitalization, clinical response, and adherence to therapy after switching from conventional antipsychotics or clozapine in a naturalistic setting of schizophrenic patients.<br />Method: Data were registered for periods of identical duration before and after switching.<br />Results: Fifty-seven patients were included. Mean study period was 3.1 +/- 0.2 years. Mean number of in-patient days after switching declined by 78% of the level before switching (P=0.0002). There was no significant differences in ratio responders/non-responders between the subgroups. The number of patients with extrapyramidal symptoms (EPS) was significantly reduced after switching. However, intolerable weight gain led to a lack of adherence to therapy in 18% of the olanzapine-treated patients.<br />Conclusion: Long-term treatment with the second generation antipsychotics, risperidone and olanzapine significantly improved the clinical outcome. However, weight gain may be a significant reason for discontinuation of treatment and reducing the long-term adherence to therapy.
- Subjects :
- Adult
Aged
Antipsychotic Agents adverse effects
Benzodiazepines
Dopamine Antagonists adverse effects
Dose-Response Relationship, Drug
Female
Hospitalization statistics & numerical data
Humans
Male
Middle Aged
Olanzapine
Pirenzepine adverse effects
Retrospective Studies
Risperidone adverse effects
Schizophrenic Psychology
Serotonin Agents adverse effects
Serotonin Antagonists administration & dosage
Selective Serotonin Reuptake Inhibitors administration & dosage
Time Factors
Treatment Outcome
Antipsychotic Agents administration & dosage
Dopamine Antagonists administration & dosage
Pirenzepine administration & dosage
Pirenzepine analogs & derivatives
Risperidone administration & dosage
Schizophrenia drug therapy
Serotonin Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0001-690X
- Volume :
- 107
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta psychiatrica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 12752030
- Full Text :
- https://doi.org/10.1034/j.1600-0447.2003.00063.x