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Biological activity of persimmon (Diospyros kaki) peel extracts.
- Source :
-
Phytotherapy research : PTR [Phytother Res] 2003 May; Vol. 17 (5), pp. 495-500. - Publication Year :
- 2003
-
Abstract
- Fractionated extracts of persimmon (Diospyros kaki) peels were studied for cytotoxic activity, multidrug resistance (MDR) reversal activity, anti-human immunodeficiency virus (HIV) activity and anti-Helicobacter pylori (H. pylori) activity. The potent cytotoxic activity against human oral squamous cell carcinoma cells (HSC-2) and human submandibular gland tumor (HSG) cells was found in the acetone fractions (A4 and A5) with IC(50) ranging from 21 to 59 micro g/mL. However, the cytotoxic activity was not correlated with the radical intensity of the fractions. Three 70% MeOH extract fractions (70M2-4) produced radical and efficiently scavenged the O(2)(-) produced by hypoxanthine and xanthine oxidase reaction. All of the fractions tested were not effective for anti-H. pylori and anti-HIV. Fractions H3 and H4 of hexane extract, and M2 and M3 of MeOH extract showed a remarkable MDR reversal activity comparable with that of (+/-)-verapamil (a positive control). These results indicate the therapeutic value of persimmon peel extracts as potential antitumor and MDR-reversing agents.<br /> (Copyright 2003 John Wiley & Sons, Ltd.)
- Subjects :
- Antineoplastic Agents, Phytogenic pharmacology
Antineoplastic Agents, Phytogenic therapeutic use
Cell Division drug effects
Drug Resistance, Multiple
Fruit chemistry
HIV-1 growth & development
Helicobacter pylori growth & development
Humans
Inhibitory Concentration 50
Plant Epidermis chemistry
Tumor Cells, Cultured drug effects
Tumor Cells, Cultured virology
Diospyros
HIV-1 drug effects
Helicobacter pylori drug effects
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0951-418X
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Phytotherapy research : PTR
- Publication Type :
- Academic Journal
- Accession number :
- 12748986
- Full Text :
- https://doi.org/10.1002/ptr.1183