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Effects of chronic exercise and imipramine on mRNA for BDNF after olfactory bulbectomy in rat.
- Source :
-
Brain research [Brain Res] 2003 Jun 06; Vol. 974 (1-2), pp. 228-35. - Publication Year :
- 2003
-
Abstract
- We examined the effects of chronic activity wheel running and antidepressant treatment on brain-derived neurotrophic factor (BDNF) messenger RNA (mRNA) in multiple brain regions-hippocampal formation (HF), ventral tegmental area/substantia nigra (VTA/SN), nucleus accumbens (NAc), and piriform cortex (PFx)-after bilateral olfactory bulbectomy (OBX). Male, Long-Evans rats (n=72) underwent either sham or OBX surgery and were randomly divided into eight experimental groups in a 2 (sham vs. OBX) x 2 (sedentary vs. activity wheel)x2 (saline vs. imipramine) factorial design. Animals were killed after 21 days of treatment. Drug x exercise interaction effects were observed for HF (P=0.006-0.023) and VTA/SN (P=0.021); exercise increased BDNF mRNA in the saline treated animals but not in the imipramine treated animals. OBX did not affect BDNF mRNA in the HF or VTA/SN (P>0.05). BDNF mRNA levels in the PFx were not altered by exercise, drug, or OBX (P>0.05). These results suggest that the effect of exercise on BDNF mRNA extends beyond the HF to the mesolimbic ventral tegmental area and that the potentiation of BDNF mRNA by exercise and antidepressant pharmacotherapy, reported by other investigators, is time limited.
- Subjects :
- Animals
Autoradiography
Behavior, Animal physiology
Brain Chemistry drug effects
Brain Chemistry physiology
In Situ Hybridization
Male
Rats
Rats, Long-Evans
Running physiology
Antidepressive Agents, Tricyclic pharmacology
Brain-Derived Neurotrophic Factor biosynthesis
Imipramine pharmacology
Olfactory Bulb physiology
Physical Conditioning, Animal physiology
Physical Exertion physiology
RNA, Messenger biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 974
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 12742641
- Full Text :
- https://doi.org/10.1016/s0006-8993(03)02584-8