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In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2003 Jun; Vol. 86 (2-3), pp. 249-52. - Publication Year :
- 2003
-
Abstract
- Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC(50) values less than 10 microg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC(50) value of 0.5 microg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.
Details
- Language :
- English
- ISSN :
- 0378-8741
- Volume :
- 86
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 12738095
- Full Text :
- https://doi.org/10.1016/s0378-8741(03)00045-x