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Combined histomorphometric and gene-expression profiling applied to toxicology.
- Source :
-
Genome biology [Genome Biol] 2003; Vol. 4 (5), pp. R32. Date of Electronic Publication: 2003 Apr 30. - Publication Year :
- 2003
-
Abstract
- We have developed a unique methodology for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology. This hybrid technology, termed extensible morphometric relational gene-expression analysis (EMeRGE), is applied in a toxicological study of time-varied vehicle- and carbon-tetrachloride (CCl4)-treated rats, and demonstrates correlations between specific genes and tissue structures that can augment interpretation of biological observations and diagnosis.
- Subjects :
- Animals
Carbon Tetrachloride toxicity
Chemical and Drug Induced Liver Injury
Data Interpretation, Statistical
Histocytochemistry methods
Liver drug effects
Liver metabolism
Liver pathology
Liver Diseases genetics
Liver Diseases pathology
Oligonucleotide Array Sequence Analysis methods
RNA genetics
RNA metabolism
Rats
Rats, Sprague-Dawley
Gene Expression Profiling
Toxicology methods
Subjects
Details
- Language :
- English
- ISSN :
- 1474-760X
- Volume :
- 4
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Genome biology
- Publication Type :
- Academic Journal
- Accession number :
- 12734012
- Full Text :
- https://doi.org/10.1186/gb-2003-4-5-r32