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Platelet dysfunction in lean women with polycystic ovary syndrome and association with insulin sensitivity.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2003 May; Vol. 88 (5), pp. 2263-8. - Publication Year :
- 2003
-
Abstract
- Platelet dysfunction and its association with insulin resistance and/or hyperandrogenemia were evaluated in 50 women with polycystic ovary syndrome (PCOS), 50 women with non-classic congenital adrenal hyperplasia (NC-CAH), and 30 women in the control group. Agonist-induced platelet aggregation was measured. Women with PCOS had significantly higher levels of platelet aggregations induced by ADP (77.4 +/- 3.3 vs. 67.3 +/- 2.8), collagen (79.7 +/- 1.8 vs. 69.1 +/- 3.9), and epinephrine (84.7 +/- 2.6 vs. 67.8 +/- 3.8), compared with controls. However platelet aggregations of women with NC-CAH because of ADP (68.2 +/- 4.22), collagen (69.5 +/- 5.4), or epinephrine (68.6 +/- 4.3) were similar to those in the control group. There were negative correlations between aggregations induced by agonists and the insulin sensitivity in women with PCOS. These correlations also appeared significant after androgen levels with covariance analysis were excluded. These covariance analyses were performed because serum androgen levels might affect platelet function. Any significant correlations were not found between androgen levels and agonist-induced platelet aggregation in women with NC-CAH. We conclude that platelet dysfunction may be an important reason for the possible cardiovascular heart diseases in women with PCOS.
- Subjects :
- Adenosine Diphosphate pharmacology
Adrenal Hyperplasia, Congenital blood
Adult
Androgens blood
Blood Platelet Disorders blood
Cardiovascular Diseases etiology
Collagen pharmacology
Epinephrine pharmacology
Female
Humans
Platelet Aggregation drug effects
Polycystic Ovary Syndrome blood
Blood Platelet Disorders etiology
Blood Platelets physiology
Insulin Resistance
Polycystic Ovary Syndrome complications
Subjects
Details
- Language :
- English
- ISSN :
- 0021-972X
- Volume :
- 88
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 12727984
- Full Text :
- https://doi.org/10.1210/jc.2002-021391