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Mixed myelodysplastic syndrome and myeloproliferative disorder with bone marrow and pulmonary fibrosis: the role of megakaryocytes.
- Source :
-
Acta haematologica [Acta Haematol] 2003; Vol. 109 (3), pp. 145-9. - Publication Year :
- 2003
-
Abstract
- The case of an 80-year-old woman displaying myelodysplastic syndrome evolving into a myeloproliferative disorder with myelofibrosis and pulmonary fibrosis, is reported. This case is characterized by an initial presentation of a myelodysplastic syndrome with normal karyotype and moderate fibrosis, its evolution towards a myeloproliferative disorder with myelofibrosis and the worsening of pulmonary fibrosis in parallel to the acceleration of the myeloproliferative disorder and myelofibrosis. These features and the high concentration of plasma platelet factor-4 suggest a role of megakaryocyte/platelet degranulation in the development of fibrosis.<br /> (Copyright 2003 S. Karger AG, Basel)
- Subjects :
- Aged
Aged, 80 and over
Cell Degranulation
Female
Humans
Myeloproliferative Disorders pathology
Platelet Factor 4 metabolism
Primary Myelofibrosis pathology
Pulmonary Fibrosis pathology
Time Factors
Megakaryocytes pathology
Megakaryocytes physiology
Myelodysplastic Syndromes complications
Myeloproliferative Disorders etiology
Primary Myelofibrosis etiology
Pulmonary Fibrosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5792
- Volume :
- 109
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 12714825
- Full Text :
- https://doi.org/10.1159/000069290