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Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia.
- Source :
-
Journal of neuroscience research [J Neurosci Res] 2003 May 15; Vol. 72 (4), pp. 461-71. - Publication Year :
- 2003
-
Abstract
- Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. We demonstrated that delayed treatment with different classes of COX inhibitor significantly blunted enhancement of dentate gyrus proliferation of neural progenitor cells after ischemia. COX-2 immunoreactivity was observed in both neurons and astrocytes in the dentate gyrus, but not in neural progenitor cells in the subgranular zone. Moreover, in the postischemic dentate gyrus of heterozygous and homozygous COX-2 knockout mice, proliferating bromodeoxyuridine-positive cells were significantly fewer than in wild-type littermates. These results demonstrate that COX-2 is an important modulator in enhancement of proliferation of neural progenitor cells after ischemia.<br /> (Copyright 2003 Wiley-Liss, Inc.)
- Subjects :
- Animals
Astrocytes drug effects
Astrocytes enzymology
Brain Ischemia genetics
Brain Ischemia physiopathology
Cell Differentiation genetics
Cell Differentiation physiology
Cell Division drug effects
Cell Division genetics
Cell Division physiology
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors pharmacology
Hippocampus cytology
Hippocampus drug effects
Hippocampus enzymology
Immunohistochemistry
Indomethacin pharmacology
Isoenzymes antagonists & inhibitors
Isoenzymes genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Neurons drug effects
Nitrobenzenes pharmacology
Prostaglandin-Endoperoxide Synthases genetics
Stem Cells drug effects
Sulfonamides pharmacology
Brain Ischemia enzymology
Isoenzymes metabolism
Neurons enzymology
Prostaglandin-Endoperoxide Synthases metabolism
Stem Cells enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0360-4012
- Volume :
- 72
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 12704808
- Full Text :
- https://doi.org/10.1002/jnr.10595