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CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis: role of gamma delta T cells in amplification of the host immune response.
- Source :
-
Infection and immunity [Infect Immun] 2003 May; Vol. 71 (5), pp. 2634-42. - Publication Year :
- 2003
-
Abstract
- According to a previous report, the degree of the host immune response highly correlates with severity of the disease in the murine model for neurocysticercosis. In wild-type mice, Mesocestoides corti infection induced a rapid and extensive accumulation of gamma delta T cells and macrophages in the brain. NK cells, dendritic cells, alpha beta T cells, and B cells were also recruited to the brain but at lower levels. In contrast, gamma delta T-cell-deficient mice exhibited decreased cellular infiltration and reduced central nervous system (CNS) pathology. To understand the mechanisms of leukocyte recruitment into the CNS, chemokine expression was analyzed in infected brains in the present study. MCP-1 (CCL2), MIP-1 alpha (CCL3), and MIP-1 beta (CCL4) were up-regulated within 2 days after M. corti infection. Protein expression of RANTES (CCL5), eotaxin (CCL11), and MIP-2 was detected later, at 1 week postinfection. Correlating with the decreased cellular infiltration, delta chain T-cell receptor-deficient (TCR delta(-/-)) mice exhibited substantially reduced levels of most of the chemokines analyzed (with the exception of eotaxin). The results suggest that gamma delta T cells play an important role in the CNS immune response by producing chemokines such as MCP-1 and MIP-1 alpha, enhancing leukocyte trafficking into the brain during murine neurocysticercosis.
- Subjects :
- Animals
Brain immunology
Brain parasitology
Cell Movement
Chemokine CCL2 biosynthesis
Chemokine CCL3
Chemokine CCL4
Female
Macrophage Inflammatory Proteins biosynthesis
Mesocestoides
Mice
Mice, Inbred C57BL
Neurocysticercosis pathology
Chemokines, CC physiology
Neurocysticercosis immunology
Receptors, Antigen, T-Cell, gamma-delta physiology
T-Lymphocytes physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 71
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 12704138
- Full Text :
- https://doi.org/10.1128/IAI.71.5.2634-2642.2003