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A cost-effectiveness analysis of universal versus selective immunization with Mycobacterium bovis bacille Calmette-Guérin in Finland.
- Source :
-
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2003 Jan; Vol. 7 (1), pp. 22-9. - Publication Year :
- 2003
-
Abstract
- Setting: Mycobacterium bovis bacille Calmette-Gueŕin (BCG) is provided to all infants born in Finland.<br />Objective: To analyze the cost-effectiveness of universal versus selective BCG immunization.<br />Design: A Markov model was developed to simulate rates of tuberculosis (TB) and non-tuberculous mycobacterial disease (NTM), and to examine the cost-effectiveness in terms of cost per case averted of three different strategies: universal BCG, selective BCG (10% of infants at higher TB risk than other infants) or no BCG immunization.<br />Results: In a cohort of 60,000 infants over 15 years, the model predicts five cases each of TB and NTM disease with universal immunization, 8-21 TB and 31 NTM cases with various strategies of selective immunization, and 25 TB and 34 NTM cases with no BCG immunization. BCG side-effects are predicted in 5, 0.5 and 0 infants, respectively. The cost per case averted for immunization strategies ranges from a cost of 38,311 US dollars to a savings of 323 dollars as selective immunization becomes more efficient at targeting infants at highest risk of TB.<br />Conclusions: In a country with a low incidence of pediatric tuberculosis, selective BCG immunization is a more cost-effective strategy than universal BCG immunization for the prevention of tuberculosis, but results in an increase in NTM cases.
- Subjects :
- BCG Vaccine administration & dosage
Cohort Studies
Cost of Illness
Cost-Benefit Analysis
Finland epidemiology
Humans
Immunization Programs organization & administration
Incidence
Infant
Markov Chains
Mass Vaccination economics
Tuberculosis epidemiology
BCG Vaccine economics
Immunization Programs economics
Patient Selection
Tuberculosis prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1027-3719
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
- Publication Type :
- Academic Journal
- Accession number :
- 12701831