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Effects of hydrocortisone and beta-aminopropionitrile on stress-strain and stress-relaxation behaviors, and birefringent retardation of collagen fibers in the rat incisor periodontal ligament.
- Source :
-
Connective tissue research [Connect Tissue Res] 2002; Vol. 43 (4), pp. 581-8. - Publication Year :
- 2002
-
Abstract
- Three groups of male Wistar rats received daily subcutaneous injections of 10 mg/kg of hydrocortisone (HC group), 300 mg/kg of beta-aminopropionitrile (BAPN group), or saline (control group), for 10 days. The shear stress-strain and stress-relaxation properties of the incisor periodontal ligament were examined in transverse sections from dissected mandibles. Both the maximum shear stress and failure strain energy density increased significantly following the administration of hydrocortisone. The maximum shear stress decreased following the administration of BAPN. However, the stress-relaxations in the initial 10 min did not show significant differences among the three groups. Polarized light microscopic analysis revealed that the retardation value of the collagen fibers was highest in the HC group and lowest in the BAPN group for the bone-related area, but not for the tooth-related and middle areas of the ligament. It is suggested that the changes induced by hydrocortisone or BAPN occurred mainly in the elastic components and to a minor extent in the viscous components although the physical and biomechanical properties are determined by the interaction of all the various components. We also suggest that the main response to the drugs occurred in the collagen fibers in the bone-related area of the ligament.
- Subjects :
- Animals
Birefringence
Elasticity drug effects
Fibrillar Collagens physiology
Incisor
Male
Microscopy, Polarization
Periodontal Ligament pathology
Periodontal Ligament physiology
Rats
Rats, Wistar
Relaxation physiology
Stress, Mechanical
Viscosity drug effects
Aminopropionitrile pharmacology
Anti-Inflammatory Agents pharmacology
Fibrillar Collagens drug effects
Hydrocortisone pharmacology
Periodontal Ligament drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0300-8207
- Volume :
- 43
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Connective tissue research
- Publication Type :
- Academic Journal
- Accession number :
- 12685864