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Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts.
- Source :
-
International journal of oncology [Int J Oncol] 2003 May; Vol. 22 (5), pp. 1135-9. - Publication Year :
- 2003
-
Abstract
- In this study, we analyzed specific anti-tumor immune responses in tumor-bearing hosts by measuring HER2-specific CD8+ T cell responses. No measurable HER2-derived peptide (HER2p63)-specific CD8+ T cells were present in the spleens of mice in the early to late phase of tumor-bearing. Vaccination with HER2 protein and cholesteryl group-bearing pullulan (CHP-HER2 complex) induced HER2-specific CD8+ T cells, but their numbers continuously declined as tumors continued growing. Removal of CD4+ T cells by anti-CD4 monoclonal antibody in the early tumor-bearing stage resulted in tumor regression. The combination of CHP-HER2 complex vaccination and depletion of CD4+ T cells enhanced and restored HER2-specific CD8+ T cells in the late stage of tumor-bearing, and also suppressed tumor growth. These results indicate the importance of manipulation of CD4+ T cells in developing effective immunotherapies as cancer vaccines.
- Subjects :
- Animals
CD4 Antigens immunology
CD8-Positive T-Lymphocytes immunology
Female
Immunosuppression Therapy
Immunotherapy
Mice
Mice, Inbred BALB C
Spleen immunology
Antibodies, Monoclonal therapeutic use
CD4-Positive T-Lymphocytes immunology
Fibrosarcoma immunology
Lymphocyte Depletion
Receptor, ErbB-2 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1019-6439
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of oncology
- Publication Type :
- Academic Journal
- Accession number :
- 12684682