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Is there a relationship between HLA type and prognostic factors in breast cancer?
- Source :
-
Anticancer research [Anticancer Res] 2003 Jan-Feb; Vol. 23 (1B), pp. 633-8. - Publication Year :
- 2003
-
Abstract
- No convincing association exists between HLA type and breast cancer development but certain HLA types have been suggested to be associated with poor risk disease. Here, the HLA type (class I and II) for 141 breast cancer patients was compared to a control population of 100 individuals and to the prognostic indicators for the patients. No association was found between HLA type and breast cancer development. Consideration of individual HLA/prognostic factor relationships previously reported confirmed that HLA-B7 was over-represented in premenopausal oestrogen-receptor (ER)-positive, grade 3 tumours (p = 0.04) and that HLA-A1 correlated positively with Nottingham Prognostic Index (p < 0.05) and with ER-negative disease (p < 0.05). These findings suggest that some previously identified associations between HLA type I and particular prognostic factors may be real, if weak but appear to conflict with the only other sizeable study investigating HLA type II in breast cancer (which negatively correlated HLA-DR 11 with early onset disease).
- Subjects :
- Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
HLA-A Antigens classification
HLA-B Antigens classification
HLA-DR Antigens classification
Humans
Middle Aged
Prognosis
Receptors, Estrogen biosynthesis
Breast Neoplasms immunology
HLA-A Antigens blood
HLA-B Antigens blood
HLA-DR Antigens blood
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 23
- Issue :
- 1B
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 12680159