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Is there a relationship between HLA type and prognostic factors in breast cancer?

Authors :
Gourley C
Thornton C
Massie C
Prescott RJ
Turner M
Leonard RC
Kilpatrick DC
Source :
Anticancer research [Anticancer Res] 2003 Jan-Feb; Vol. 23 (1B), pp. 633-8.
Publication Year :
2003

Abstract

No convincing association exists between HLA type and breast cancer development but certain HLA types have been suggested to be associated with poor risk disease. Here, the HLA type (class I and II) for 141 breast cancer patients was compared to a control population of 100 individuals and to the prognostic indicators for the patients. No association was found between HLA type and breast cancer development. Consideration of individual HLA/prognostic factor relationships previously reported confirmed that HLA-B7 was over-represented in premenopausal oestrogen-receptor (ER)-positive, grade 3 tumours (p = 0.04) and that HLA-A1 correlated positively with Nottingham Prognostic Index (p < 0.05) and with ER-negative disease (p < 0.05). These findings suggest that some previously identified associations between HLA type I and particular prognostic factors may be real, if weak but appear to conflict with the only other sizeable study investigating HLA type II in breast cancer (which negatively correlated HLA-DR 11 with early onset disease).

Details

Language :
English
ISSN :
0250-7005
Volume :
23
Issue :
1B
Database :
MEDLINE
Journal :
Anticancer research
Publication Type :
Academic Journal
Accession number :
12680159