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Memory extinction requires gene expression in rat hippocampus.
- Source :
-
Neurobiology of learning and memory [Neurobiol Learn Mem] 2003 May; Vol. 79 (3), pp. 199-203. - Publication Year :
- 2003
-
Abstract
- Rats with cannulae in the dorsal CA1 region of the hippocampus were trained in one-trial step-down inhibitory avoidance, and submitted to four consecutive daily test sessions without the footshock. This produced extinction of the conditioned response in control animals. The bilateral infusion into the CA1 region of the dorsal hippocampus of two different inhibitors of gene transcription, DRB (80 microg/side) or alpha-amanitin (25 pg/side), or of the protein synthesis inhibitor, anisomycin (80 microg/side) blocked extinction of the CR. The treatments were effective when given 15 min before, but not 1 or 3h after the first test session. Retrieval itself was not affected by the drugs. The treatments did not affect general activity in an open field or anxiety levels measured in an elevated plus maze. The data indicate that gene transcription and protein synthesis are necessary at the time of the first test session in order to generate extinction. These requirements are to be expected from learning that involves new synaptic associations.
- Subjects :
- Amanitins administration & dosage
Amanitins pharmacology
Animals
Dichlororibofuranosylbenzimidazole administration & dosage
Dichlororibofuranosylbenzimidazole pharmacology
Enzyme Inhibitors administration & dosage
Enzyme Inhibitors pharmacology
Male
Maze Learning drug effects
RNA, Messenger antagonists & inhibitors
Rats
Rats, Wistar
Extinction, Psychological
Gene Expression drug effects
Hippocampus drug effects
Memory drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1074-7427
- Volume :
- 79
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neurobiology of learning and memory
- Publication Type :
- Academic Journal
- Accession number :
- 12676518
- Full Text :
- https://doi.org/10.1016/s1074-7427(03)00003-0