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[Pentylenetetrazole kindling induces caspase-3 activation in rat brain].
- Source :
-
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 2003 Jan-Feb; Vol. 53 (1), pp. 110-2. - Publication Year :
- 2003
-
Abstract
- Pentylenetetrazole kindling (but not a single pentylenetetrazole injection) induced caspase-3 activation in the cerebral cortex, hippocampus, and cerebellum of rats as well as neurodegeneration in the hippocampus. The number of neurons in the CA3 subfield of the hippocampus decreased significantly, whereas no apoptotic nuclei could be detected. The results support a possible non-apoptotic involvement of caspase-3 in brain plasticity.
- Subjects :
- Animals
Behavior, Animal drug effects
Caspase 3
GABA Antagonists administration & dosage
Male
Pentylenetetrazole administration & dosage
Rats
Rats, Wistar
Caspases metabolism
GABA Antagonists pharmacology
Hippocampus drug effects
Hippocampus enzymology
Kindling, Neurologic drug effects
Pentylenetetrazole pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0044-4677
- Volume :
- 53
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
- Publication Type :
- Academic Journal
- Accession number :
- 12669512