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Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: comparison with clinical and radiologic examinations.
- Source :
-
Head & neck [Head Neck] 2003 Apr; Vol. 25 (4), pp. 280-8. - Publication Year :
- 2003
-
Abstract
- Background: Neck metastasis is a major prognostic factor of head and neck carcinoma, but its preoperative detection is currently unreliable. Molecular markers of the metastatic potential of a carcinoma would help to avoid unnecessary neck dissection in patients with nonmetastatic cancer.<br />Methods: The fractions of cancer cells immunostained for proliferating cell nuclear antigen (PCNA) and Ki67 were determined in 80 preoperative biopsy specimens of head and neck carcinomas. The value of both indexes to detect metastasis in the subsequent neck dissection was compared with that of the clinical and radiologic examinations.<br />Results: PCNA and Ki67 indexes correlated with neck metastasis. Cutoff points were determined for both indexes to discriminate metastatic from nonmetastatic carcinomas. By multivariate logistic regression, these indexes were significant predictors of metastases, together with clinical T stage and neck palpation.<br />Conclusion: The fraction of cancer cells immunolabeled for PCNA or Ki67 in preoperative biopsy specimens is helpful to predict neck metastasis.<br /> (Copyright 2003 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell immunology
Female
Humans
Immunohistochemistry
Laryngeal Neoplasms immunology
Lymphatic Metastasis immunology
Magnetic Resonance Imaging
Male
Middle Aged
Mouth Neoplasms immunology
Pharyngeal Neoplasms immunology
Predictive Value of Tests
Reproducibility of Results
Sensitivity and Specificity
Tomography, Spiral Computed
Carcinoma, Squamous Cell diagnosis
Carcinoma, Squamous Cell secondary
Cell Fractionation
Ki-67 Antigen immunology
Laryngeal Neoplasms diagnosis
Laryngeal Neoplasms pathology
Lymphatic Metastasis diagnostic imaging
Lymphatic Metastasis pathology
Mouth Neoplasms diagnosis
Mouth Neoplasms pathology
Pharyngeal Neoplasms diagnosis
Pharyngeal Neoplasms pathology
Proliferating Cell Nuclear Antigen immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1043-3074
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 12658732
- Full Text :
- https://doi.org/10.1002/hed.10218