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In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.

Authors :
Crowell AL
Sanders-Lewis KA
Secor WE
Source :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2003 Apr; Vol. 47 (4), pp. 1407-9.
Publication Year :
2003

Abstract

The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.

Details

Language :
English
ISSN :
0066-4804
Volume :
47
Issue :
4
Database :
MEDLINE
Journal :
Antimicrobial agents and chemotherapy
Publication Type :
Academic Journal
Accession number :
12654679
Full Text :
https://doi.org/10.1128/AAC.47.4.1407-1409.2003