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Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.
- Source :
-
Genes & development [Genes Dev] 2003 Mar 15; Vol. 17 (6), pp. 729-37. - Publication Year :
- 2003
-
Abstract
- Neural progenitor cells often produce distinct types of neurons in a specific order, but the determinants that control the sequential generation of distinct neuronal subclasses in the vertebrate CNS remain poorly defined. We examined the sequential generation of visceral motor neurons and serotonergic neurons from a common pool of neural progenitors located in the ventral hindbrain. We found that the temporal specification of these neurons varies along the anterior-posterior axis of the hindbrain, and that the timing of their generation critically depends on the integrated activities of Nkx- and Hox-class homeodomain proteins. A primary function of these proteins is to coordinate the spatial and temporal activation of the homeodomain protein Phox2b, which in turn acts as a binary switch in the selection of motor neuron or serotonergic neuronal fate. These findings assign new roles for Nkx, Hox, and Phox2 proteins in the control of temporal neuronal fate determination, and link spatial and temporal patterning of CNS neuronal fates.
- Subjects :
- Animals
Bromodeoxyuridine pharmacology
Cell Lineage
Homeobox Protein Nkx-2.2
Homeodomain Proteins metabolism
Immunohistochemistry
In Situ Hybridization
Mice
Microscopy, Fluorescence
Models, Biological
Mutation
Neurons metabolism
Time Factors
Transcription Factors metabolism
Zebrafish Proteins
Brain embryology
Central Nervous System embryology
Gene Expression Regulation, Developmental
Homeodomain Proteins genetics
Motor Neurons metabolism
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0890-9369
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Genes & development
- Publication Type :
- Academic Journal
- Accession number :
- 12651891
- Full Text :
- https://doi.org/10.1101/gad.255803