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Electrical stimulation prevents deterioration of the oxidative capacity of disuse-atrophied muscles in rats.
- Source :
-
Aviation, space, and environmental medicine [Aviat Space Environ Med] 2003 Mar; Vol. 74 (3), pp. 207-11. - Publication Year :
- 2003
-
Abstract
- Introduction: The purpose of this study was to evaluate the effects of electrical stimulation on disuse-atrophied muscles.<br />Methods: Sprague-Dawley rats were used and divided into three groups: control (C), hind-limb suspended for 7 d (HS), and HS plus transcutaneous electrical stimulation for 7 d (ES). In the ES group, transcutaneous electrical stimulation was induced at 1 Hz for 1 h every day to condition the gastrocnemius-plantaris-soleus muscles. Muscle oxidative capacity was evaluated by 31P-MRS in vivo. Maximum tension and muscle wet mass were also measured.<br />Results: Muscle oxidative capacity decreased within 1 wk in HS; however, it was maintained when electric stimulation was applied to the suspended limb. The maximum twitch tension in HS was significantly smaller than that in C (p < 0.05), while in ES it did not differ from that in C. The muscle mass was significantly smaller in the HS and ES groups compared to C (p < 0.05).<br />Conclusion: These data indicated that twitch electrical stimulation was effective in preventing deterioration of muscle functions, such as maximum tension and oxidative capacity, induced by 1 wk of disuse.
- Subjects :
- Animals
Atrophy
Disease Models, Animal
Electric Stimulation
Male
Muscle Contraction physiology
Muscular Disorders, Atrophic veterinary
Rats
Rats, Sprague-Dawley
Muscle, Skeletal pathology
Muscle, Skeletal physiology
Muscular Disorders, Atrophic physiopathology
Muscular Disorders, Atrophic prevention & control
Oxygen Consumption
Space Flight
Subjects
Details
- Language :
- English
- ISSN :
- 0095-6562
- Volume :
- 74
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Aviation, space, and environmental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12650266