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Impact of renal transplantation on small vessel reactivity.
- Source :
-
Transplantation [Transplantation] 2003 Mar 15; Vol. 75 (5), pp. 689-97. - Publication Year :
- 2003
-
Abstract
- Background: The function of large arteries is altered after renal transplantation. Whether transplantation also induces agonist-dependent functional changes in small arterial renal and extrarenal vessels has not yet been studied.<br />Methods: Chronic rejection was induced by grafting Lewis rats with kidneys from Fischer rats (FL). Rats that underwent transplantation were bilaterally nephrectomized. Rats that underwent syngeneic transplantation, uninephrectomized rats, uninephrectomized rats with denervated kidneys or with kidneys made ischemic, and native rats served as controls. All animals were treated with cyclosporine for 10 days. Eighteen weeks after surgery, the reactivity of small arteries (220-270 microm) was tested by myography.<br />Results: Weight gain, glomerular filtration rate, and arterial pressure were similar in all groups, whereas proteinuria was elevated in FL. Only kidneys from FL showed glomerular lesions, tubular atrophy, and vasculopathy. Responsiveness of coronary, mesenteric, and femoral resistance vessels to both constrictor and dilator agonists was similar in transplanted and nontransplanted animals. Resistance vessels obtained from both allogeneically and syngeneically transplanted kidneys were more sensitive to norepinephrine, phenylephrine, angiotensin II, and vasopressin than renal vessels from weight-matched controls. Vasodilation in response to acetylcholine and sodium nitroprusside was mitigated in transplanted versus nontransplanted kidneys.<br />Conclusions: In rat renal transplantation, renal resistance vessel responsiveness to constrictor or dilator stimuli is altered. Extrarenal small vessel function is not affected. The changes in function of renal resistance vessels are not explained by reduction of nephron mass, denervation, ischemia, or chronic rejection.
- Subjects :
- Angiotensin II pharmacology
Animals
Arginine Vasopressin pharmacology
Arteries
Blood Vessels drug effects
Blood Vessels physiopathology
Coronary Vessels physiopathology
Femoral Artery physiopathology
Kidney pathology
Male
Mesenteric Arteries physiopathology
Microcirculation
Norepinephrine pharmacology
Phenylephrine pharmacology
Rats
Rats, Inbred F344
Vascular Resistance
Vasoconstrictor Agents pharmacology
Kidney Transplantation
Renal Circulation
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1337
- Volume :
- 75
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 12640311
- Full Text :
- https://doi.org/10.1097/01.TP.0000044111.12370.ED