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Intravaginal clindamycin to reduce preterm birth in women with abnormal genital tract flora.
- Source :
-
Obstetrics and gynecology [Obstet Gynecol] 2003 Mar; Vol. 101 (3), pp. 516-22. - Publication Year :
- 2003
-
Abstract
- Objective: To assess the ability of clindamycin vaginal cream to reduce the incidence of preterm birth in women with abnormal genital tract flora in the second trimester of pregnancy.<br />Methods: This was a randomized, double-blind, placebo-controlled, tricenter study. A total of 409 women with abnormal genital tract flora on Gram stain of vaginal secretions at 13-20 weeks' gestation were randomized to receive a 3-day course of clindamycin vaginal cream or placebo. Those women who still had abnormal vaginal flora 3 weeks later received a 7-day course of the original study drug (ie, either clindamycin vaginal cream or placebo as per original randomization). The primary outcome measure was the incidence of preterm birth.<br />Results: There was a statistically significant reduction in the incidence of preterm birth in the clindamycin vaginal cream group (4%) compared with placebo (10%) (P <.03). Significantly more babies born preterm (63%) required admission to the neonatal intensive care unit compared with term infants (4%) (P <.001).<br />Conclusion: A 2% clindamycin vaginal cream, when compared with placebo administered to women with abnormal genital tract flora before 20 weeks' gestation, can reduce the incidence of preterm birth by 60% and hence the need for neonatal intensive care.
- Subjects :
- Administration, Intravaginal
Adolescent
Adult
Anti-Bacterial Agents administration & dosage
Birth Weight
Clindamycin administration & dosage
Double-Blind Method
England
Female
Humans
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Second
Treatment Outcome
Vagina microbiology
Anti-Bacterial Agents therapeutic use
Clindamycin therapeutic use
Obstetric Labor, Premature prevention & control
Pregnancy Complications, Infectious prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0029-7844
- Volume :
- 101
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 12636956
- Full Text :
- https://doi.org/10.1016/s0029-7844(02)03054-5