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The role of IFN-gamma in tumor transplantation immunity and inhibition of chemical carcinogenesis.
- Source :
-
Current opinion in immunology [Curr Opin Immunol] 2003 Apr; Vol. 15 (2), pp. 148-54. - Publication Year :
- 2003
-
Abstract
- IFN-gamma contributes to the rejection of transplantable tumors and the inhibition of methylcholanthrene (MCA)-induced carcinogenesis by different mechanisms. In most tumor transplantation models, tumor rejection requires IFN-gamma receptor expression by host cells, but not by tumor cells. IFN-gamma produced by either CD4+ or CD8+ T cells acts on non-hematopoietic tumor stroma cells and, either directly or indirectly, induces angiostasis. This prevents rapid tumor burden and allows residual tumor cells to be eliminated. In some models, IFN-gamma also contributes to the destruction of existing tumor blood vessels. During MCA-induced tumorigenesis IFN-gamma is involved in the inhibition of MCA diffusion by encapsulation and reduction of DNA damage. This mechanism may primarily protect tissue from damage and simultaneously inhibit tumor development.
- Subjects :
- Animals
Carcinogens administration & dosage
Graft Rejection metabolism
Graft Rejection physiopathology
Humans
Interferon-gamma immunology
Interferon-gamma metabolism
Methylcholanthrene administration & dosage
Neoplasm Transplantation immunology
Neoplasms chemically induced
Neoplasms immunology
Graft Rejection immunology
Interferon-gamma physiology
Neoplasms physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0952-7915
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current opinion in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 12633663
- Full Text :
- https://doi.org/10.1016/s0952-7915(03)00007-4