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Phenytoin-induced toxic cholestatic hepatitis in a patient with skin lesions: case report.
- Source :
-
Southern medical journal [South Med J] 2003 Feb; Vol. 96 (2), pp. 201-3. - Publication Year :
- 2003
-
Abstract
- Phenytoin is a highly effective and widely prescribed anticonvulsant agent, but it can be associated with dose-related side effects and hypersensitivity reactions. We present a case of phenytoin-induced cholestatic hepatotoxicity in a 47-year-old woman who had exfoliative dermatitis, an increase in liver enzymes with a cholestatic pattern, and eosinophilia after 25 days of phenytoin therapy. The diagnostic workup showed no other possible causes, and the results of a percutaneous liver biopsy were consistent with drug-induced toxic hepatitis. Within 3 weeks after discontinuing phenytoin therapy, her liver function tests returned to normal values.
- Subjects :
- Anticonvulsants therapeutic use
Chemical and Drug Induced Liver Injury pathology
Cholestasis pathology
Dermatitis, Exfoliative pathology
Female
Humans
Middle Aged
Phenytoin therapeutic use
Seizures prevention & control
Anticonvulsants adverse effects
Chemical and Drug Induced Liver Injury etiology
Cholestasis chemically induced
Dermatitis, Exfoliative chemically induced
Phenytoin adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0038-4348
- Volume :
- 96
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Southern medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 12630649
- Full Text :
- https://doi.org/10.1097/01.SMJ.0000051269.23361.4A