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A study of the immunology, virology, and safety of prednisone in HIV-1-infected subjects with CD4 cell counts of 200 to 700 mm(-3).
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2003 Mar 01; Vol. 32 (3), pp. 281-6. - Publication Year :
- 2003
-
Abstract
- Adult Clinical Trials Group Study 349 examined the immunology, virology, and safety of 40 mg/d prednisone as an adjunct to antiretroviral therapy in 24 HIV-infected subjects with >200 CD4+ T cells/mm in a randomized placebo-controlled trial. After 8 weeks, median lymphocyte and CD4+ cell numbers increased >40% above baseline values (p =.08). No effect was observed on markers of cell activation or apoptosis, although the proportion of CD28+ CD8+ T cells increased (p =.006). Prednisone inhibited monocyte TNFalpha production without affecting T-cell responses to antigens or mitogens. Two subjects assigned to prednisone were subsequently found to have asymptomatic osteonecrosis of the hip. Many questions remain regarding the role of activation-induced sequestration and apoptosis as causes of progressive CD4+ T-cell loss in AIDS. The potential role of corticosteroids as tools to examine this question will be limited by concerns regarding their toxicity; however, further studies of other agents to limit cellular activation in AIDS are warranted.
- Subjects :
- Adult
Anti-HIV Agents therapeutic use
Apoptosis
CD28 Antigens analysis
CD4 Lymphocyte Count
CD8 Antigens analysis
Double-Blind Method
Drug Therapy, Combination
HIV Infections immunology
HIV Infections virology
Hip diagnostic imaging
Humans
Lymphocyte Count
Osteonecrosis chemically induced
Osteonecrosis diagnostic imaging
Prednisolone adverse effects
Prednisolone antagonists & inhibitors
RNA, Viral blood
Radiography
T-Lymphocytes immunology
T-Lymphocytes pathology
Treatment Outcome
Tumor Necrosis Factor-alpha analysis
Tumor Necrosis Factor-alpha biosynthesis
HIV Infections drug therapy
HIV-1 genetics
HIV-1 isolation & purification
Prednisolone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1525-4135
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 12626887
- Full Text :
- https://doi.org/10.1097/00126334-200303010-00006