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Subsensitivity to beta-adrenergic stimulation in atria from rats infested with Syphacia sp.
- Source :
-
Laboratory animals [Lab Anim] 2003 Jan; Vol. 37 (1), pp. 63-7. - Publication Year :
- 2003
-
Abstract
- Syphacia sp. is a common intestinal parasite in conventionally-housed laboratory rodents. Although gross lesions are rare in oxyuriasis, it is possible that more subtle changes may develop, which may affect research results. In this study, we analysed the responsiveness to beta-adrenergic stimulation by isoproterenol (ISO) of left atria isolated from Syphacia-infested (SYPH) and control, non-infested adult male Wistar rats (CONT). In the non-infested animals, ISO pD(2) was not significantly changed by ivermectin treatment. Whereas the maximal inotropic response to ISO was not significantly affected, the pD(2) value was decreased in SYPH (7.61 +/- 0.09, n = 7, vs 8.21 +/- 0.25 in CONT, n = 5, P < 0.05), indicating lower sensitivity to beta-adrenergic stimulation. This change was similar to that caused by a classic stressor, namely repeated immobilization, in non-infested rats (IMMO). In this group, ISO pD(2) was 7.62 +/- 0.14, n = 6 (P < 0.05 with relation to CONT). The results indicate that infestation with Syphacia sp. is as effective as immobilization at diminishing cardiac reactivity to beta-adrenergic stimulation. It is thus possible that oxyuriasis may affect the response of other tissues to physiological modulators.
- Subjects :
- Animals
Anthelmintics therapeutic use
Heart physiopathology
Heart Atria drug effects
Heart Atria physiopathology
Isoproterenol pharmacology
Ivermectin therapeutic use
Male
Oxyuriasis drug therapy
Oxyuriasis physiopathology
Rats
Rats, Wistar
Restraint, Physical
Rodent Diseases physiopathology
Stress, Physiological physiopathology
Stress, Physiological veterinary
Adrenergic beta-Agonists pharmacology
Heart drug effects
Oxyuriasis veterinary
Oxyuroidea
Rodent Diseases parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 0023-6772
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Laboratory animals
- Publication Type :
- Academic Journal
- Accession number :
- 12626073
- Full Text :
- https://doi.org/10.1258/002367703762226700