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Antifungal activity of biflavones from Taxus baccata and Ginkgo biloba.
- Source :
-
Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2003 Jan-Feb; Vol. 58 (1-2), pp. 65-9. - Publication Year :
- 2003
-
Abstract
- Bilobetin and 4'''-O-methylamentoflavone were isolated and identified in the needles of Taxus baccata, for the first time in this species. The antifungal activity of biflavones from T. baccata and Ginkgo biloba, namely amentoflavone, 7-O-methylamentoflavone, bilobetin, ginkgetin, sciadopitysin and 2,3-dihydrosciadopitysin towards the fungi Alternaria alternata, Fusarium culmorum, Cladosporium oxysporum was determined employing computer-aided image analysis couplet to a microscope. Bilobetin exhibited a significant antifungal activity with values of ED50 14, 11 and 17 microM respectively. This compound completely inhibited the growth of germinating tubes of Cladosporium oxysporum and Fusarium culmorum at a concentration 100 microM. Activity of ginkgetin and 7-O-methylamentoflavone towards Alternaria alternata was stronger than that of bilobetin. Moreover, slight structural changes in the cell wall of Alternaria alternata exposed to ginkgetin at concentration of 200 microM were observed.
- Subjects :
- Alternaria drug effects
Antifungal Agents chemistry
Antifungal Agents isolation & purification
Cladosporium drug effects
Flavonoids isolation & purification
Fusarium drug effects
Microbial Sensitivity Tests
Antifungal Agents pharmacology
Biflavonoids
Flavonoids chemistry
Flavonoids pharmacology
Ginkgo biloba chemistry
Taxus chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0939-5075
- Volume :
- 58
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Zeitschrift fur Naturforschung. C, Journal of biosciences
- Publication Type :
- Academic Journal
- Accession number :
- 12622229
- Full Text :
- https://doi.org/10.1515/znc-2003-1-212