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Enforced proximity in the function of a famous scaffold.

Authors :
Ferrell JE Jr
Cimprich KA
Source :
Molecular cell [Mol Cell] 2003 Feb; Vol. 11 (2), pp. 289-91.
Publication Year :
2003

Abstract

Recent studies by Park, Zarrinipar, and Lim with reengineered Ste5 scaffold proteins underscore the fundamental importance of proximity in enzyme regulation and of keeping a proper distance for maintaining signaling specificity.

Subjects

Subjects :
Carrier Proteins genetics
Genes, Fungal
Models, Biological
Mutation
Protein Engineering
Saccharomyces cerevisiae chemistry
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae physiology
Saccharomyces cerevisiae Proteins genetics
Signal Transduction
Adaptor Proteins, Signal Transducing
Carrier Proteins physiology
Saccharomyces cerevisiae Proteins physiology

Details

Language :
English
ISSN :
1097-2765
Volume :
11
Issue :
2
Database :
MEDLINE
Journal :
Molecular cell
Publication Type :
Academic Journal
Accession number :
12620218
Full Text :
https://doi.org/10.1016/s1097-2765(03)00055-8
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