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Serological markers in inflammatory bowel diseases.
- Source :
-
Best practice & research. Clinical gastroenterology [Best Pract Res Clin Gastroenterol] 2003 Feb; Vol. 17 (1), pp. 19-35. - Publication Year :
- 2003
-
Abstract
- This chapter is an overview of the literature on serological markers of inflammatory bowel diseases (IBD), focusing on anti-neutrophil cytoplasm autoantibodies (ANCA) and anti- Saccharomyces cerevisiae mannan antibodies (ASCA). The methodology for ANCA and ASCA testing is first introduced. The value of these markers as diagnostic tools is then discussed. Other chapters are devoted to the potential role of ANCA and ASCA in disease monitoring, disease stratification and as subclinical markers in families. Finally reviewed are other antibodies recently tested in clinical trials such as pancreatic antibodies and antibodies directed against bacterial antigens. The role of these antibodies in the pathophysiology of IBD still needs to be assessed. We also need to identify the ASCA immunogen(s) eliciting the antibody response.
- Subjects :
- Antibodies, Antineutrophil Cytoplasmic blood
Antibodies, Fungal blood
Humans
Inflammatory Bowel Diseases blood
Inflammatory Bowel Diseases physiopathology
Mass Screening
Antibodies, Antineutrophil Cytoplasmic immunology
Antibodies, Fungal immunology
Biomarkers blood
Inflammatory Bowel Diseases diagnosis
Inflammatory Bowel Diseases immunology
Saccharomyces cerevisiae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-6918
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Best practice & research. Clinical gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 12617880
- Full Text :
- https://doi.org/10.1053/bega.2002.0347