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Embolic attack in patients with atrial fibrillation and atrial thrombus depends on the character of the thrombus.
- Source :
-
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2003 Mar; Vol. 67 (3), pp. 203-8. - Publication Year :
- 2003
-
Abstract
- It is very important to prevent embolisms from left atrial thrombi (LAT). The present study was a trial for the management of patients with AT using 122 patients with atrial fibrillation and LAT who were followed for 1 year after transesophageal echocardiography. LAT were classified by their shape and mobility into the mobile ball type (MB, n=28), fixed ball type (FB, n=32) and mountain type (MO, n=42). The patients were given warfarin (INR: 1.5-2.0, n=43), aspirin 81 mg (n=74) and/or ticlopidine 200 mg/day (n=31). The embolic rate (ER) in the MB group was significantly higher than in the other groups [ie, MB 39.3% vs FB 15.6% (p<0.05), vs MO 2.4% (p<0.05)]. The ER in the FB group was significantly higher than in the MO group (p<0.05). Therapy with a combination of ticlopidine and aspirin reduced the ER in the patients with ball thrombi. The ER of the ball thrombus type group, especially the MB group, was very high in spite of therapy with anti-coagulants and/or anti-platelet agents, and such patients should be treated by early surgical intervention. However, the combination of ticlopidine and aspirin may be useful for preventing embolism.
- Subjects :
- Aged
Aspirin therapeutic use
Disease-Free Survival
Drug Therapy, Combination
Echocardiography, Transesophageal
Embolism prevention & control
Female
Humans
Male
Middle Aged
Practice Guidelines as Topic
Predictive Value of Tests
Survival Analysis
Thrombosis classification
Thrombosis drug therapy
Thrombosis pathology
Ticlopidine therapeutic use
Warfarin therapeutic use
Atrial Fibrillation complications
Embolism etiology
Heart Atria pathology
Thrombosis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1346-9843
- Volume :
- 67
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Publication Type :
- Academic Journal
- Accession number :
- 12604867
- Full Text :
- https://doi.org/10.1253/circj.67.203