TGFbeta-induced factor: a candidate gene for high myopia.

Authors :: Lam DS
Lee WS
Leung YF
Tam PO
Fan DS
Fan BJ
Pang CP
Source :: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2003 Mar; Vol. 44 (3), pp. 1012-5.
Publication Year :: 2003
Abstract: Purpose: To investigate the coding exons of transforming growth factor (TGF)-beta-induced factor (TGIF) for mutations in Chinese patients with high myopia.<br />Methods: Seventy-one individuals with high myopia of -6.00 D or less and 105 control subjects were screened by DNA sequencing for sequence alterations. Univariate analysis and logistic regression were performed to identify single-nucleotide polymorphisms (SNPs) and their interactions in TGIF that may be associated with myopia.<br />Results: Six SNPs showed a significant difference (P < 0.05) between patient and control subject in univariate analysis. Four of them cause codon changes: G223R, G231S, P241T, and A262G. Among all the SNPs that entered multivariate analysis, only 657(T-->G) showed statistical significance in the logistic regression model (odds ratio 0.133; 95% confidence interval 0.037-0.488; P = 0.002).<br />Conclusions: TGIF is a probable candidate gene for high myopia. Further studies are needed to identify the underlying mechanism.