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Interleukin-2-associated viral breakthroughs induce HIV-1-specific CD4 T cell responses in patients on fully suppressive highly active antiretroviral therapy.
- Source :
-
AIDS (London, England) [AIDS] 2003 Mar 07; Vol. 17 (4), pp. 628-9. - Publication Year :
- 2003
-
Abstract
- The combination of intermittent subcutaneous IL-2 and highly active antiretroviral therapy in individuals infected with HIV-1 has been shown to have a beneficial quantitative effect on the CD4 T cell count. We observed IL-2-associated viral load 'blips' inducing HIV-1-specific lymphoproliferative responses at 24 weeks in such individuals. This immunotherapeutic approach, utilizing autologous virus as autovaccination, may be a viable, safer alternative to structured treatment interruption and potentially more efficacious than therapeutic vaccines.
Details
- Language :
- English
- ISSN :
- 0269-9370
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 12598786
- Full Text :
- https://doi.org/10.1097/00002030-200303070-00020