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The effect of nerve growth factor on the early responses during the process of wound healing.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2003 Mar 17; Vol. 1620 (1-3), pp. 25-31. - Publication Year :
- 2003
-
Abstract
- In this study, we investigated the role of nerve growth factor (NGF)-incorporated collagen on wound healing in rats. Full-thickness excision wounds were made on the back of female rats weighing about 150-160 g. Topical application of NGF-incorporated collagen, at a concentration of 1 microg/1.2 mg collagen/cm(2), once a day, for 10 days resulted in complete healing of wounds on the 15th day. The concentrations of collagen, hexosamine and uronic acid in the granulation tissue were determined. The NGF-incorporated collagen-treated rats required shorter duration for the healing with an increased rate of wound contraction. Histological and electron microscopical evaluations were also performed, which reveal the activation of fibroblasts and endoplasmic reticulum and therefore increased level of collagen synthesis due to NGF application. These results clearly indicate that the topical application of NGF-incorporated collagen enhanced the rate of healing of excision wounds.
- Subjects :
- Administration, Topical
Animals
Collagen chemistry
Collagen pharmacology
Female
Granulation Tissue chemistry
Granulation Tissue metabolism
Microscopy, Electron
Nerve Growth Factor chemistry
Nerve Growth Factor physiology
Rats
Skin chemistry
Skin ultrastructure
Time Factors
Wound Healing physiology
Collagen biosynthesis
Nerve Growth Factor pharmacology
Skin injuries
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1620
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 12595069
- Full Text :
- https://doi.org/10.1016/s0304-4165(02)00501-9