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Insulin: does it induce follicular arrest in the rat ovary?
- Source :
-
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2002 Oct; Vol. 16 (5), pp. 361-4. - Publication Year :
- 2002
-
Abstract
- The goal of this study was to investigate histological changes of the rat ovary treated with either insulin or insulin plus human chorionic gonadotropin (hCG). The study was conducted in Celal Bayar University, School of Medicine, Animal Research Laboratory. Eighteen adult female Wistar rats were divided into three groups to receive saline, or insulin, or insulin plus hCG for 4 weeks. At the end of treatment the rats were sacrificed and the ovaries were evaluated with hematoxylin and eosin. There was no abnormal change in rats treated with saline. A thickened capsule, stromal hypertrophy and stromal cell hyperplasia, and no developing follicles, were observed in the insulin-only group. A thin capsule, developing follicles and corpora lutea, and normal theca cells and stroma were observed in the insulin-plus-hCG group. We conclude that insulin may lead to histological changes similar to stromal hyperthecosis and polycystic ovary syndrome, and may be one of the factors causing follicular arrest.
- Subjects :
- Animals
Chorionic Gonadotropin pharmacology
Corpus Luteum
Female
Granulosa Cells ultrastructure
Hyperplasia
Hypertrophy
Mitosis
Ovary drug effects
Ovary pathology
Polycystic Ovary Syndrome pathology
Rats
Rats, Wistar
Stromal Cells pathology
Theca Cells ultrastructure
Insulin pharmacology
Ovarian Follicle drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0951-3590
- Volume :
- 16
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 12587529
- Full Text :
- https://doi.org/10.1080/gye.16.5.361.364