[Study on the release mechanism of fenoprofen calcium from hydrophillic sustained-release matrix].

Authors :: Zhao CS
He ZG
Cui SM
Tang X
Zhang RH
Source :: Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2001 Jan; Vol. 36 (1), pp. 63-6.
Publication Year :: 2001
Abstract: Aim: To study the release mechanism of fenoprofen calcium (FC) from hydroxypropylmethylcellulose (HPMC) matrices.<br />Methods: The release of FC and the erosion properties of hydrophillic matrices containing HPMC was examined at different paddle speed. The release mechanism of FC was further confirmed by evaluating the n value in Peppas equation.<br />Results: The results indicate that the release of FC and the erosion of matrices exhibit zero order kinetic equation, and it exhibits line relationship between them.<br />Conclusion: In the first 40 min, FC mainly released by diffusion and erosion from HPMC matrix, while it was controlled by the rate of tablet erosion after 50 min.

Subjects :: Delayed-Action Preparations chemistry
Hypromellose Derivatives
Methylcellulose chemistry
Fenoprofen chemistry
Methylcellulose analogs & derivatives

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