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Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study.
- Source :
-
Circulation [Circulation] 2003 Feb 11; Vol. 107 (5), pp. 747-52. - Publication Year :
- 2003
-
Abstract
- Background: Because elastase in alpha(1)-antitrypsin deficiency may attack elastin in the arterial wall, we tested whether alpha(1)-antitrypsin deficiency is associated with reduced blood pressure, risk of ischemic cerebrovascular (ICVD) and ischemic heart disease (IHD), and longevity.<br />Methods and Results: We genotyped 7963 control subjects from the adult general population of Denmark, 1131 Danish patients with ICVD, and 2221 Danish patients with IHD. Compared with MM/MS individuals, systolic blood pressure was lower by 15 mm Hg in ZZ homozygotes (n=6, P=0.03) and 9 mm Hg in MZ heterozygotes with IHD (n=39, P=0.02). Odds ratios for ICVD and IHD in MZ versus MM/MS individuals were 0.70 (0.51 to 0.96) and 0.77 (0.61 to 0.98). Finally, mean ages of MZ and MM/MS control subjects were 58 and 56 years (Mann-Whitney: P=0.008), and relative alpha(1)-antitrypsin MZ genotype frequencies increased from 20 to 93 years among control subjects (chi(2), P=0.002).<br />Conclusions: ZZ alpha(1)-antitrypsin deficiency and MZ intermediate deficiency in the context of IHD are associated with reduced blood pressure, and MZ is associated with reduced risk of ICVD and IHD. Because MZ heterozygosity was associated with increased age, MZ heterozygosity could be a beneficial condition.
- Subjects :
- Adult
Age Distribution
Aged
Aged, 80 and over
Comorbidity
Denmark epidemiology
Female
Gene Frequency
Genetic Testing
Genotype
Homozygote
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Polymorphism, Genetic
Reference Values
Risk Assessment
Blood Pressure genetics
Brain Ischemia epidemiology
Myocardial Ischemia epidemiology
alpha 1-Antitrypsin Deficiency epidemiology
alpha 1-Antitrypsin Deficiency genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4539
- Volume :
- 107
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Circulation
- Publication Type :
- Academic Journal
- Accession number :
- 12578879
- Full Text :
- https://doi.org/10.1161/01.cir.0000049642.20484.5d