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Structural and energetic processes related to P300: LORETA findings in depression and effects of antidepressant drugs.
- Source :
-
Methods and findings in experimental and clinical pharmacology [Methods Find Exp Clin Pharmacol] 2002; Vol. 24 Suppl D, pp. 85-91. - Publication Year :
- 2002
-
Abstract
- Noninvasive electrophysiological neuroimaging applied to cognitive components of event-related potentials (ERPs) may differentiate between structural and energetic processes related to information processing. The structural level, revealed by the location of the local maxima of the current source density distribution, describes the time-dependent network of activated brain areas. The magnitude of the source strength, a measure of the energetic component, describes the allocation of processing resources. ERPs were recorded in an odd-ball paradigm and low-resolution brain electromagnetic tomography (LORETA) was applied for standard and target ERP components. In a group of 60 menopausal depressed patients of 45-60 years of age, reduced P300 source strength was observed bilaterally, temporally and medially prefrontally reaching to rostal parts of the anterior cingulate, compared with 29 age-matched controls. In a double-blind, placebo-controlled study, 2 mg of the antidepressant citalopram induced a significant increase of P300 source strength in the (left) prefrontal cortex and precuneus compared with placebo, reaching to the posterior cingulate. Similar increases were observed after 800 mg S-adenosyl-L-methionine (SAMe) administered intravenously in ten young healthy subjects aged 22-33, and they were even more pronounced in ten elderly healthy subjects aged 56-71. Thus, ERP-tomography identified changes in energetic sources in brain areas predominantly involved in depression and in antidepressant action.
- Subjects :
- Acoustic Stimulation methods
Adult
Aged
Depressive Disorder physiopathology
Double-Blind Method
Electromagnetic Phenomena
Event-Related Potentials, P300 physiology
Female
Humans
Male
Middle Aged
Postmenopause physiology
Tomography methods
Antidepressive Agents pharmacology
Antidepressive Agents therapeutic use
Depressive Disorder drug therapy
Event-Related Potentials, P300 drug effects
Postmenopause drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0379-0355
- Volume :
- 24 Suppl D
- Database :
- MEDLINE
- Journal :
- Methods and findings in experimental and clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 12575474