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TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2003 Feb 15; Vol. 170 (4), pp. 1814-21. - Publication Year :
- 2003
-
Abstract
- The Newcastle disease virus (NDV) has antineoplastic and immunostimulatory properties, and it is currently clinically tested in anticancer therapy. However, the tumoricidal mechanisms of NDV tumor therapy are not fully understood. The results presented here demonstrate that NDV-stimulated human monocytes (Mphi) kill various human tumor cell lines and that this tumoricidal activity is mediated by TRAIL. In contrast to soluble TRAIL-R2-Fc, soluble CD95-Fc and TNF-R2-Fc showed only minimal blocking of the antitumor effect. TRAIL expression is induced on human Mphi after stimulation with NDV and UV-inactivated NDV. These results show that TRAIL induction on human Mphi after NDV stimulation is independent from viral replication and that TRAIL mediates the tumoricidal activity of NDV-stimulated human Mphi.
- Subjects :
- Antigens, CD biosynthesis
Antigens, CD physiology
Apoptosis Regulatory Proteins
Cell Membrane immunology
Cell Membrane metabolism
Cytotoxicity Tests, Immunologic
GPI-Linked Proteins
Humans
Ligands
Membrane Glycoproteins biosynthesis
Membrane Proteins biosynthesis
Membrane Proteins physiology
Monocytes metabolism
Newcastle disease virus physiology
Receptors, TNF-Related Apoptosis-Inducing Ligand
Receptors, Tumor Necrosis Factor biosynthesis
Receptors, Tumor Necrosis Factor physiology
Receptors, Tumor Necrosis Factor, Member 10c
Receptors, Tumor Necrosis Factor, Type I
Receptors, Tumor Necrosis Factor, Type II
TNF-Related Apoptosis-Inducing Ligand
Tumor Cells, Cultured immunology
Tumor Cells, Cultured pathology
Tumor Cells, Cultured virology
Tumor Necrosis Factor Decoy Receptors
Tumor Necrosis Factor-alpha biosynthesis
Up-Regulation immunology
Virus Replication immunology
fas Receptor biosynthesis
fas Receptor physiology
Apoptosis immunology
Macrophage Activation immunology
Membrane Glycoproteins physiology
Monocytes immunology
Monocytes virology
Newcastle disease virus immunology
Tumor Necrosis Factor-alpha physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 170
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 12574346
- Full Text :
- https://doi.org/10.4049/jimmunol.170.4.1814