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Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression.
- Source :
-
The EMBO journal [EMBO J] 2003 Feb 17; Vol. 22 (4), pp. 870-81. - Publication Year :
- 2003
-
Abstract
- In a process called quorum sensing, bacteria communicate with one another by exchanging chemical signals called autoinducers. In the bioluminescent marine bacterium Vibrio harveyi, two different auto inducers (AI-1 and AI-2) regulate light emission. Detection of and response to the V.harveyi autoinducers are accomplished through two two-component sensory relay systems: AI-1 is detected by the sensor LuxN and AI-2 by LuxPQ. Here we further define the V.harveyi quorum-sensing regulon by identifying 10 new quorum-sensing-controlled target genes. Our examination of signal processing and integration in the V.harveyi quorum-sensing circuit suggests that AI-1 and AI-2 act synergistically, and that the V.harveyi quorum-sensing circuit may function exclusively as a 'coincidence detector' that discriminates between conditions in which both autoinducers are present and all other conditions.
Details
- Language :
- English
- ISSN :
- 0261-4189
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The EMBO journal
- Publication Type :
- Academic Journal
- Accession number :
- 12574123
- Full Text :
- https://doi.org/10.1093/emboj/cdg085