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PACAP in avians: origin, occurrence, and receptors--pharmacological and functional considerations.
- Source :
-
Current pharmaceutical design [Curr Pharm Des] 2003; Vol. 9 (6), pp. 467-81. - Publication Year :
- 2003
-
Abstract
- Pituitary adenylate cyclase-activating polypeptide (PACAP) is a novel member of the secretin/glucagon/vasoactive intestinal peptide (VIP) superfamily. In vertebrates, including avians, it occurs in two forms: PACAP(38) and PACAP(27). PACAP structure is well conserved during evolution, being identical in mammals, and showing one amino acid dfifference in avians (chick, turkey). PACAP is widely distributed in the central nervous system and peripheral tissues and displays a pleiotropic activity, including functions as a hypophysiotropic hormone, neuromodulator, and neurotrophic factor. PACAP exerts its biological actions through three types of receptors designated PAC(1), VPAC(1) and VPAC(1). This review (1) presents the current knowledge on PACAP origin, distribution and function, (2) compares the avian findings with those found in mammals, and (3) describes receptor-linked mechanisms in avians, including recent data on receptor-related signal transduction pathways, with a special emphasis on receptor pharmacology and function.
- Subjects :
- Amino Acid Sequence
Animals
Brain physiology
Evolution, Molecular
Neuropeptides antagonists & inhibitors
Neuropeptides chemistry
Neurotransmitter Agents chemistry
Peripheral Nervous System physiology
Pituitary Adenylate Cyclase-Activating Polypeptide
Protein Conformation
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
Receptors, Pituitary Hormone classification
Receptors, Pituitary Hormone physiology
Sequence Homology, Amino Acid
Signal Transduction physiology
Tissue Distribution
Birds physiology
Neuropeptides physiology
Neurotransmitter Agents physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1381-6128
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current pharmaceutical design
- Publication Type :
- Academic Journal
- Accession number :
- 12570810
- Full Text :
- https://doi.org/10.2174/1381612033391586