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Tor signalling in bugs, brain and brawn.
- Source :
-
Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2003 Feb; Vol. 4 (2), pp. 117-26. - Publication Year :
- 2003
-
Abstract
- TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.
- Subjects :
- Animals
Drosophila melanogaster
Humans
Drosophila Proteins physiology
Phosphatidylinositol 3-Kinases physiology
Phosphotransferases (Alcohol Group Acceptor) physiology
Receptor Protein-Tyrosine Kinases physiology
Saccharomyces cerevisiae Proteins physiology
Signal Transduction
Tacrolimus Binding Protein 1A physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-0072
- Volume :
- 4
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nature reviews. Molecular cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 12563289
- Full Text :
- https://doi.org/10.1038/nrm1018