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Lichenoid reaction caused by Clopidogrel, a new anti-platelet drug.

Authors :
Guijarro Guijarro B
López Sánchez AF
Source :
Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal [Med Oral] 2003 Jan-Feb; Vol. 8 (1), pp. 33-7.
Publication Year :
2003

Abstract

The case is described of a 71-year-old woman presenting with acute erosive lichen planus. The lesions appeared one week after starting treatment with clopidogrel (Plavix), a new antiplatelet drug, for the prevention of cerebral thrombosis. The patient presented erosive lesions on both jugal mucosal surfaces and the lateral sides of the tongue, associated with intense pain. The clinical diagnosis of erosive lichen planus induced by clopidogrel was confirmed by histological biopsy evaluation. Clopidogrel was replaced by aspirin, which was the antiplatelet drug previously used by the patient, and 0.1% triamcinolone acetonide in orabase was prescribed in combination with systemic corticoids. The erosive lesions and pain disappeared as a result, though asymptomatic reticular lesions typical of lichen planus persisted.

Details

Language :
English; Spanish; Castilian
ISSN :
1137-2834
Volume :
8
Issue :
1
Database :
MEDLINE
Journal :
Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal
Publication Type :
Academic Journal
Accession number :
12556721