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Cognitive and motor functioning in gene carriers for Huntington's disease: a baseline study.
- Source :
-
The Journal of neuropsychiatry and clinical neurosciences [J Neuropsychiatry Clin Neurosci] 2003 Winter; Vol. 15 (1), pp. 7-16. - Publication Year :
- 2003
-
Abstract
- The aim of this study was to investigate the first changes in cognitive and motor functioning in Huntington's disease. Forty-six gene carriers, not clinically diagnosed for HD, were compared with 88 non-gene carriers. Gene carriers performed significantly worse on the Benton Visual Retention Test. This result was due to a minority of participants who had already developed cognitive impairment. Marginal differences appeared on the motor times of single reaction time measures after correction for motor signs. The findings are discussed in the context of inconsistencies in previous studies and underscore the need for longitudinal research.
- Subjects :
- Adolescent
Adult
Aged
Cognition Disorders genetics
Diagnosis, Differential
Female
Genetic Testing
Humans
Huntington Disease genetics
Male
Mental Status Schedule statistics & numerical data
Middle Aged
Psychometrics
Psychomotor Disorders genetics
Reaction Time genetics
Reaction Time physiology
Cognition Disorders diagnosis
Genetic Carrier Screening
Huntington Disease diagnosis
Neuropsychological Tests
Psychomotor Disorders diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0895-0172
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of neuropsychiatry and clinical neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 12556566
- Full Text :
- https://doi.org/10.1176/jnp.15.1.7