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[A histopathologic and immunohistochemical study of 68 cases of hemangioblastoma].
- Source :
-
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao [Hua Xi Yi Ke Da Xue Xue Bao] 2000 Sep; Vol. 31 (3), pp. 380-2. - Publication Year :
- 2000
-
Abstract
- The aim of this study was to evaluate the histologic characteristics of hemangioblastoma (HB) and investigate the histogenesis of its stromal cells. Sixty-eight cases of hemangioblastoma were studied by light microscopy and thirty-three cases were examined by immunohistochemical stainning. Forty-eight of the 68 patients were males and 20 were females. The average age was 37. Fifty-two cases (76.6%) had been present for two months to one year before the diagnosis was made. Sixty cases (88.2%) arose in the cerebellum. Fifty cases (73.5%) appeared as cystic nodules. Histologically, the 68 cases of HB were further categorized into three subtypes: typical (30 cases), cellular (21 cases) and reticular (17 cases). In 33 cases, the stromal cell were positive for NSE, but negative for F-VIII, UEA-1, GFAP and EMA. In summary, there are three essential histologic categories of hemangioblastoma, and its stromal cells may well have the characters of neuroendocrine differentiation.
- Subjects :
- Adolescent
Adult
Cerebellar Neoplasms metabolism
Child
Female
Glioma metabolism
Glioma pathology
Hemangioblastoma metabolism
Humans
Immunohistochemistry
Male
Middle Aged
Neuroendocrine Tumors pathology
Phosphopyruvate Hydratase analysis
Stromal Cells pathology
Cerebellar Neoplasms pathology
Hemangioblastoma pathology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0257-7712
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao
- Publication Type :
- Academic Journal
- Accession number :
- 12545840